Equivalence test: Ratio of parameter estimates

Add one or several equivalence tests for the ratio of the Test or Control sample parameter over the Standard sample parameter to your assay. To add the tests as assay suitability tests, add them as children of the Assay suitability tests element. To add the tests as sample suitability tests, add them as children of the Sample suitability tests element.

Important: Test definitions are ignored without notification if the parameter you select results in invalid test definitions (for example, if a test cannot be performed for the model you use).

The following table lists all available tests and indicates which models and assay elements they support:

Equivalence test on the ratio of the: Linear parallel-line model 4-parameter logistic model 5-parameter logistic model 3-parameter logistic model with fixed lower or upper asymptote Slope ratio model Assay elements
Upper asymptotes (A) (nonlinear models) no yes yes with fixed Lower asymptote no Test, Control
B parameters (nonlinear models) no yes yes yes no Test, Control
Lower asymptotes (D) (nonlinear models) no yes yes with fixed Upper asymptote no Test, Control
Asymmetry parameters (G) (nonlinear models) no no yes no no Test, Control
Intercepts (linear models) no no no no yes Test, Control
Slopes (linear models) yes no no no yes Test, Control
Differences of asymptotes (A - D) (nonlinear models)* no yes yes no no Test, Control

* The 'difference of asymptotes' is the difference of the Upper minus the Lower asymptote of an assay element. This value is always based on the unrestricted regression model. The present test examines the ratio of such values, that is, of (1) the value for the Test or Control sample to (2) the value for the Standard sample.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...unbounded optional none

Context:

/Quantitative response assay/Analysis/Suitability tests/Assay suitability tests/alternatives/

/Quantitative response assay/Analysis/Suitability tests/Sample suitability tests/alternatives/

/Test system definition (Quantitative response assay)/Suitability tests/Assay suitability tests/alternatives/

/Test system definition (Quantitative response assay)/Suitability tests/Sample suitability tests/alternatives/