M–R
Find reference information on document elements of the Dichotomous Assay Package, letters M to R.
Maximal group number
The Maximal group number limits the number of observation groups (assay elements) for which the Observations editor can display data.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:positiveInteger | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/Column: Observation Group/
Meaning
Enter text to specify the signatures this document requires.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Document Suitability Tests/choice/Signature state/
Memo column (factor)
Define a column that allows you to associate each observation with a multiline text.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...unbounded | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/choice/
Model: Logit
Uses the Logit regression model to estimate relative potency.
Select a different model from the drop-down list if you require.
The model is defined by the following equation:
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Empty | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Analysis/Analytical Model/choice/
Model: Probit
Uses the Probit regression model to estimate relative potency.
Select a different model from the drop-down list if you require.
The model is defined by the following equation:
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Empty | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Analysis/Analytical Model/choice/
Name
Enter a name for the Control sample.
Examples:
'Assay control', 'Control 3', 'Ctr'
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Control Sample/
Name
Enter a name for this column.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:string | 0...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/Column: Observation Group/
Name
Enter a name for this document.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/
Name
Enter a name for the Preparation scheme.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/
Name
Enter a name for the Test sample.
Examples:
'Preparation 1', 'Unknown 3', 'Test 2'
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Test Sample/
Name
Enter a name for the Standard sample.
Examples:
'Standard', 'Std', 'Reference standard'
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Standard Sample/
Number of signatures
Enter a number to specify how many signatures this document requires.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:double | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Document Suitability Tests/choice/Signature state/
Number of steps
Enter a number to specify how many dose steps this sequence requires.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:positiveInteger | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/choice/Geometric sequence/
Observation data
This section allows you to modify the data table that displays observation data in the Observations editor.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/
Observation group (factor)
Links individual observations (measurements) to their assay elements. All observations of a group belong to the same assay element.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/
Observation group ID
Displays the Observation group ID.
When you create an assay element, a unique Observation group ID is automatically assigned. Since Observation group IDs are required to be unique within assays, we do not recommend to change them manually.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:positiveInteger | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Standard Sample/
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Test Sample/
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Control Sample/
Observation source
Select how you want to obtain observation data. The following options are available from the drop-down list:
- User input: Enter data manually.
- Aggregation: Specify document references to aggregate data from documents.
- Import: Not supported.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/
Operator
This section allows you to provide information on an operator. Expand the node to add or view information.
To add an Operator name or reference: Select the required option from the drop-down list, and enter the name or reference.
To assign a role to the operator: Add the Role element from the Creatable elements pane, and enter the required role.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...unbounded | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/
Operator name
Enter the name of the operator.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Operator/choice/
Operator reference
Select an operator document.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Operator/choice/
p
Enter the significance level (alpha) for the p-value of the test. A common value is 0.05.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:double | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Chi-Square-Test / Z-Test (Hypothesis Test)/choice/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Chi-Square-Test / Z-Test (Hypothesis Test)/choice/
Potency estimation confidence level
Select the confidence level of the potency confidence interval. A common value is 95%.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:double | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Analysis/Analytical Model/
Predilution factor
Enter a single predilution factor. The calculation uses the reciprocal value (1 / Predilution factor).
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:double | 0...unbounded | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/Predilution factors/
Predilution factors
Select this option if you want to provide predilution factors directly. To add a Predilution factor: Double-click Predilution factor in the Creatable elements pane. When the assays are analyzed, a final predilution factor is calculated by multiplying all predilution factors entered here.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/
Preparation scheme
Assign a Preparation scheme to this assay element. Preparation schemes define dilution sequences, absolute potencies, and predilution settings of assay elements.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:string | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Standard Sample/
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Test Sample/
/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Control Sample/
Preparation scheme
This section allows you to define a Preparation scheme. Preparation schemes contain settings on dose sequence, absolute potency, and predilution factors. Expand the node to add or view information.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...unbounded | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/
Preparation schemes
This section allows you to set up multiple Preparation schemes to define doses and dimensions of your treatments. Expand the node to add or view information.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/
Probability: Data plot
Change settings to adjust display of data plots for the probability fit.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/
Probability: Full model
Change settings to adjust display of full models for the probability fit.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/
Probability: Restricted model
Change settings to adjust display of restricted models for the probability fit.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/
Property key
Select a Property key to identify the data to be aggregated.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/Column: Observation Group/
Property key
Select the key of the document property you want to use. Only documents in which an element has this property key will be considered for the import.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/Document property filter/
Property key
Select the key of the document property you want to use. The key specifies which data element of the linked document is to be imported into this document.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/Document property import/
Property key
Select the key of the section property you want to use. Only documents in which an element has this property key will be considered for the import.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/Section property filter/
Property key
Select the key of the section property you want to use. The key specifies which data element of the linked document is to be imported into this document.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/Section property import/
Property scope
Select a Property scope from the drop-down list.
The following options are available to specify the source of the aggregated property:
- Document
- Section
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/Column: Observation Group/
Reagent
This section allows you to provide information on a reagent. Expand the node to add or view information.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...unbounded | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/
Reagent batch/lot number
Enter the reagent batch or lot number, a combination of numbers, letters, and/or symbols. It identifies a batch (or lot), which allows you to infer the production and distribution history.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/
Reagent class
Enter the class of the reagent such as the drug class.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/
Reagent description
Enter a description of the reagent.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:string | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/
Reagent identification
Enter information to identify the reagent.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/
Reagent name
Enter a name for the reagent.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/choice/
Reagent reference
Select a reagent document.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/choice/
Reagent sub-batch/sub-lot number
Enter the reagent sub-batch or sub-lot number, a combination of numbers, letters, and/or symbols. It identifies a sub-batch (or sub-lot), which allows you to infer the production and distribution history.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/
Reagent variant
Enter the variant of the reagent.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Reagent/
Replicate count
Enter a number to specify how many replicates this assay element requires for each dose step.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:positiveInteger | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/
Response (affected)
Displays the number of affected responses.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/
Response (tested)
Displays the total number of tested responses.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 1...1 | required | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/
Role
Enter the role of the operator.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:token | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Documentation/Operator/
Rounding
Apply a Rounding setting to have the test round values prior to evaluation.
The following options are available:
- No rounding
- x decimal places (where x is an integer from 0 to 10)
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
xs:string | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Chi-Square-Test / Z-Test (Hypothesis Test)/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: Relative Potency Value/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: Relative-potency confidence interval/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: Relative-potency range (%)/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: Weight (W)/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: EC50 value/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Chi-Square-Test / Z-Test (Hypothesis Test)/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: Relative Potency Value/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: Relative-potency confidence interval/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: Relative-potency range (%)/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: Weight (W)/
/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: EC50 value/
Row order
Select the sort order you want to apply to the data rows.
This element has the following attributes:
Data type | Multiplicity | Usage | Default value |
Node | 0...1 | optional | none |
Context:
/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/