E–L

Find reference information on document elements of the Dichotomous Assay Package, letters E to L.

Edit mode

Select the Edit mode.

The following options are available:

  • Select: Allows you to select an existing document.
  • Create: Allows you both to select an existing document and to create a new document.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/

Equipment

This section allows you to document the equipment used to perform this assay. Expand the node to add or view information.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...unbounded optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/

Equipment name

Enter the name of the equipment.

Tip: You can enter a reference to an equipment document instead. Select the Equipment reference option from the drop-down list.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/Equipment/choice/

Equipment reference

Select an equipment document.

Tip: You can enter an equipment name instead. Select the Equipment name option from the drop-down list.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/Equipment/choice/

Exclude from analysis

Select the 'yes' option from the drop-down list to exclude this assay element from analysis. Or select 'no' to include it.

Note: If you exclude an assay element from analysis, the related assay, data, and settings (such as test definitions for the assay element) are completely ignored. But the report states that the assay element is excluded from analysis.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Test Sample/

Field

Enter the name of the property you want to import.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:Name 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/Section property import/

File name

Automatically inserts the file name of the data source when you import data.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/Data Source/

First dose

Enter a number to specify the First dose of this sequence.

Note: The number you enter must be a non-negative decimal.

The dose value for step number 'j' of a linear sequence is given by:

First Dose + Delta ⋅ ( Step Number - 1)

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:double 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/choice/Linear Sequence/

Floating-point number column (factor)

Define a column that allows you to associate each observation with a value of double-precision floating-point number format.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...unbounded required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/choice/

Folder key

Select a folder to require referenced documents be elements of this folder.

Tip: Add an Allow subfolderselement and select theTrueoption from its drop-down list to require referenced documents be elements of the specified folder or one of its subfolders.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/

Generator key

Enter a document key to require referenced documents be generated by a document that matches the key.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Comment/Linked Document/Config/

Geometric sequence

Allows you to define an n-fold geometric sequence. That is, each term after the first is found by multiplying the previous by a fixed number. Select a different sequence type from the drop-down list if you require.

The dose value for step number 'j' of an n-fold sequence is given by:

First Dose ⋅ Base (1 - j)

Example:

Initial value Base 1st step 2nd step 3rd step n-th step
= Initial value = Initial value / Base = Initial value / Base^2 = Initial value / Base^n
1 2 1.0 0.5 0.25 1 * 2^(1-n)
8 2 8.0 4.0 2.0 8* 2^(1-n)
1 0.5 1.0 2.0 4.0 1* (1/2)^(1-n)
5 3 5.0 1.67 0.56 5* 3^(1-n)

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/choice/

Graphics

This section allows you to define how graphs are displayed. Add elements to change the settings for Data plot, Full model, and Restricted model.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Settings/

Group

Enter a group name to mark the Test sample for inclusion in a combination calculation.

Note: The group does not affect assay calculations.
Note: The group only affects combination documents if they reference assay documents that have the group. In this case, all accessible Test samples of the group are included in the combination calculations.
Note: Assay results used in combination calculations are assumed to be independent.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Test Sample/

Identification

Enter a string to identify this document by this string rather than its name.

Note: We recommend to use unique identification strings. But this is not required.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/

Import comment

Enter text to provide additional information on the data import.

Tip: You can enter multiline text.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:string 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/Data Source/

Import module identification

Automatically inserts information that allows you to identify the import module used to import data.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/Data Source/

Import time stamp

Automatically inserts the current date and time when you import data.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:dateTime 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/Data Source/

Initial value

Enter a number to specify the Initial value of this sequence. The number you enter must be a non-negative decimal.

The dose value for step number 'j' of an n-fold sequence is given by:

First Dose ⋅ Base (1 - j)

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:double 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/choice/Geometric sequence/

Initial value

Enter a number to specify the Initial value of this sequence. The number you enter must be a non-negative decimal.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:double 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/choice/Stepwise dilution sequence/

Integer column (factor)

Define a column that allows you to associate each observation with a value of integer number format.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...unbounded required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Observation Data/choice/

Invert potency

Select the 'yes' option from the drop-down list to have the potency ratio inverted.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Analysis/Analytical Model/Advanced Settings/

Key

Enter a key to identify the user variable.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Documentation/User Variable/

/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Standard Sample/User Variable/

/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Test Sample/User Variable/

/Dichotomous Assay (Quantal Response Assay)/Setup/Assay Elements/Control Sample/User Variable/

Key

Enter the key of a user variable for the test.

This element has the following attributes:

Data type Multiplicity Usage Default value
1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Document Suitability Tests/choice/Test on user variable/

Label of the response unit

Enter a unit for the x-axis.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Data Plot/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Full Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Restricted Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Data Plot/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Full Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Restricted Model/

Label of the x-axis

Enter a name for the x-axis.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Data Plot/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Full Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Restricted Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Data Plot/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Full Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Restricted Model/

Label of the y-axis

Enter a name for the y-axis.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 0...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Data Plot/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Full Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Linear Predictor: Restricted Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Data Plot/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Full Model/

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/Probability: Restricted Model/

Linear predictor: Data plot

Change settings to adjust display of data plots for the linear predictor.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/

Linear predictor: Full model

Change settings to adjust display of full models for the linear predictor.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/

Linear predictor: Restricted model

Change settings to adjust display of restricted models for the linear predictor.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...1 optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Settings/Graphics/

Linear sequence

Allows you to define a linear sequence, that is, each term after the first is found by adding a fixed number to the previous. Select a different sequence type from the drop-down list if you require.

The dose value for step number 'j' of a linear sequence is given by:

First Dose + Delta ⋅ ( Step Number - 1)

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Setup/Preparation Schemes/Preparation Scheme/choice/

Linked document

Select a document.

This element has the following attributes:

Data type Multiplicity Usage Default value
Node 0...unbounded optional none

Context:

/Dichotomous Assay (Quantal Response Assay)/Comment/

Logarithm base

Specifies the logarithm base to be used for dose or response transformation. The following options are available from the drop-down list:

  • Binary logarithm (base 2)
  • Natural logarithm (base e)
  • Decimal logarithm (base 10)

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:token 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Analysis/Analytical Model/Advanced Settings/

Lower margin

Enter the Lower margin of the test as decimal number. To pass the test, the observed value must be greater than or equal to the Lower margin.

Note: Additional information is provided on the help page of the test.
Tip: Set up an Equivalence margin document in PLA if you have historical data to determine the margins for your tests.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:double 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: Weight (W)/

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: Weight (W)/

Lower margin

Enter the Lower margin of the test as decimal number. The Lower margin must be less than or equal to the Upper margin of the test.

Note: Additional information is provided on the help page of the test.
Tip: Set up an Equivalence margin document in PLA if you have historical data to determine the margins for your tests.

This element has the following attributes:

Data type Multiplicity Usage Default value
xs:double 1...1 required none

Context:

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: Relative Potency Value/

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: Relative-potency confidence interval/

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Assay Suitability Tests/choice/Test: EC50 value/

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: Relative Potency Value/

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: Relative-potency confidence interval/

/Dichotomous Assay (Quantal Response Assay)/Analysis/Suitability Tests/Sample Suitability Tests/choice/Test: EC50 value/